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28,000-Year-Old Woolly Mammoth Cells Show Biological Signs Of Life

Baby Wooly Mammoth being Thawed

The 28,000-year-old woolly mammoth was dug out of Siberian permafrost in 2011. Now scientists have found that its DNA is partially intact.

Eight years ago, an impressively well-preserved woolly mammoth was dug out of the Siberian permafrost. With the species having met its extinction some 4,000 years ago, finding such a relatively pristine specimen was an astounding feat — particularly since this one was 28,000 years old.

According to Fox News, cells from the 28,000-year-old specimen have shown “signs of biological activities” after being infused into mouse oocytes — cells found in ovaries that are capable of forming an egg cell after genetic division.

“This suggests that, despite the years that have passed, cell activity can still happen and parts of it can be recreated,” said study author Kei Miyamoto from the Department of Genetic Engineering at Kindai University. “Until now many studies have focused on analyzing fossil DNA and not whether they still function.”

The process to establish whether the mammoth DNA could still function wasn’t easy. According to IFL Science, researchers began by taking bone marrow and muscle tissue samples from the animal’s leg. These were then analyzed for the presence of undamaged nucleus-like structures, which, once found, were extracted.

Once these nuclei cells were combined with mouse oocytes, mouse proteins were added, revealing some of the mammoth cells to be perfectly capable of nuclear reconstitution. This, finally, suggested that even 28,000-year-old mammoth remains could harbor active nuclei.

Five of the cells even showed highly unexpected and very promising results, namely signs of activity that usually only occur immediately preceding cell division. The study maintains, however, that there’s much work left to be done.

“In the reconstructed oocytes, the mammoth nuclei showed the spindle assembly, histone incorporation and partial nuclear formation; however, the full activation of nuclei for cleavage was not confirmed,” the study said.

“We want to move our study forward to the stage of cell division, but we still have a long way to go,” said Miyamoto.

While most mammoths died out between 14,000 and 10,000 years ago, this particular mammoth — which the research team has dubbed “Yuka” — belonged to a resilient population of the species that managed to live in the Arctic Ocean’s Wrangel Island until 4,000 years ago..

https://allthatsinteresting.com/reanimated-woolly-mammoth-cells

 

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